Treating severe malaria: artesunate or quinine?
نویسنده
چکیده
Severe (complicated) malaria caused by Plasmodium falciparum kills over a million people every year. The annual death toll can be as high as one in 100 children under the age of five(1). Intravenous infusion of quinine is recommended as an initial therapy for these children. Recent years have witnessed increasing use of artemisinin derivatives (mainly artesunate) in the treatment of severe malaria. This systematic review from the Cochrane Library compared artesunate with quinine for treating severe malaria.
منابع مشابه
Clinical Pharmacology of the Antimalarial Quinine in Children
Quinine is the best studied drug for treating severe malaria in very young children. Quinine may be administered in pregnancy and, at therapeutic doses, malformations have not been reported. Some strains of quinine from Southeast Asia and South America have become resistant. Quinine is the treatment of choice for the drug-resistant severe Plasmodium falciparum. The antimalarial mechanism of qui...
متن کاملTreating Severe Malaria in Pregnancy: A Review of the Evidence
Severe malaria in pregnancy is a large contributor to maternal morbidity and mortality. Intravenous quinine has traditionally been the treatment drug of choice for severe malaria in pregnancy. However, recent randomized clinical trials (RCTs) indicate that intravenous artesunate is more efficacious for treating severe malaria, resulting in changes to the World Health Organization (WHO) treatmen...
متن کاملCost-effectiveness of parenteral artesunate for treating children with severe malaria in sub-Saharan Africa.
OBJECTIVE To explore the cost-effectiveness of parenteral artesunate for the treatment of severe malaria in children and its potential impact on hospital budgets. METHODS The costs of inpatient care of children with severe malaria were assessed in four of the 11 sites included in the African Quinine Artesunate Malaria Treatment trial, conducted with over 5400 children. The drugs, laboratory t...
متن کاملArtesunate versus quinine for treating severe malaria.
BACKGROUND Severe malaria results in over a million deaths every year, most of them in children aged under five years and living in sub-Saharan Africa. This review examines whether treatment with artesunate, instead of the standard treatment quinine, would result in fewer deaths and better treatment outcomes. OBJECTIVES To compare artesunate with quinine for treating severe malaria. SEARCH ...
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The simian parasite Plasmodium knowlesi causes severe human malaria; the optimal treatment remains unknown. We describe the clinical features, disease spectrum, and response to antimalarial chemotherapy, including artemether-lumefantrine and artesunate, in patients with P. knowlesi malaria diagnosed by PCR during December 2007-November 2009 at a tertiary care hospital in Sabah, Malaysia. Fifty-...
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عنوان ژورنال:
- Indian pediatrics
دوره 45 1 شماره
صفحات -
تاریخ انتشار 2008